Malaria is a common and life-threatening disease in many tropical and subtropical countries. Malaria is transmitted to humans by the bite of an infected female anopheles
mosquito. P. falciparum is the only species associated with severe morbidity and mortality. In Sub-Saharan Africa over 90% of human malaria infections are due to P. falciparum infection.The other three species cause milder illness, however infections with P. ovale and P. vivax may relapse months later if appropriate treatment is not provided. Mixed infections involving more than one species may also occur.